Chromosulfuric Acid
Cayman Chemical DecnoIc AcId-d3 50mg
A depolarizing neuromuscular blocking agent a partial agonist of muscle-type nAChRs activates a1B1-containing adult mouse muscle-type nAChRs expressed in X laevis oocytes (EC50 40 UM) a nondepolarizing antagonist of neuronal-type nAChRs inhibiting mouse a7- a3B2- a3B4- and a4B2-containing receptors (IC50s 7 4 405 28 and 59 UM respectively) a competitive antagonist of a4B2-containing nAChRs expressed in SH-EP1 cells (IC50 52 UM for the human receptor) inhibits electric eel AChE blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED95 values of 35 and 70 Ug/kg for cats under chloralose and ether anesthesia respectively
Cayman Chemical N-AcetylnuramInIc AcId 250mg
Selective inhibitor of aldo-keto reductase 1C1 (AKR1C1 Ki 4 nM) versus AKR1C2 AKR1C3 and AKR1C4 (Ki 0.087 4.2 and 18.2 M respectively) potently inhibits the metabolism of progesterone in endothelial cells overexpressing AKR1C1 (IC50 460 nM)
Cayman Chemical NIcotInurIc AcId 500mg
An anticancer agent inhibits the proliferation of MCF-7 and MDA-MB-231 cells (IC50s 0.0858 and 4.2 UM respectively) as well as migration and invasion by MDA-MB-231 cells in vitro induces expression of CHIP in MDA-MB-231 cells in an AHR-dependent manner inhibits MDA-MB-231-derived CSC mammosphere formation at 1 UM reduces tumor volume and the number of metastases in an MDA-MB-231 mouse xenograft model at 15 mg/kg
Cayman Chemical PentacosnoIc AcId 500mg
An ellagitannin found in pomegranates that is reported to produce antioxidant anti-inflammatory and anticancer effects prevents accumulation of cardiac triglyceride and cholesterol via AMPK-mediated modulation of mitochondria and phase II enzymes
Cayman Chemical 11 Z-EIcosenoIc AcId 250mg
A potent selective and cell-permeable inhibitor of the BRPF1 bromodomain (IC50 80 nM) disrupts chromatin binding of BRPF1 in a cellular assay by blocking the interaction of BRPF1 with histone H3 3
Cayman Chemical MurIdeoxycholIc AcId 1mg
A second messenger produced by bacteria that regulates chemotaxis colonization and other bacterial functions binds weakly to STING (Kd 1 04 UM) induces IFN-B mRNA expression in L929 cells (EC50 10 5 nM)
Cayman Chemical 8 Z-EIcosenoIc AcId 250mg
An inhibitor of midasin inhibits the growth of fission yeast strains in vitro (GI50 136 nM) inhibits mdn1 ATPase activity by approximately 40 at 1 UM inhibits pre-rRNA processing and nuclear export of the pre-60S ribosome subunit in mdn1-ts but not mdn1-F1093L mutant S pombe cells decreases Rsa4 levels in Rix1 particles Rix1-bound Ytm1 levels and Rix7 and Ppp1 levels in Nsa1 particles in mdn1-ts fission yeast cells
Cayman Chemical D-PyrohomoglutamIc AcId 500mg
A triterpenoid sapogenin inhibits IL-1B and ROS production from LPS-induced mouse BV2 microglia at 4 M decreases NLRP3 inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced mouse model of Parkinsons disease at 25 mg/kg per day reduces increases in lung edema and BALF IL-1B and TNF-a levels in a mouse model of intranasal S aureus-induced pneumonia at 2 mg/kg
Cayman Chemical MethylmalonIc AcId-d3 50mg
A myeloperoxidase inhibitor (IC50 0 2 UM in a cell-free assay) enhances decreases in the mitochondrial membrane potential in and the viability of MOLM-14 cells when used in combination with cytarabine prevents high-fat diet-induced increases in microvascular blood flow and microvascular blood volume in rats at 75 Umol/kg